NFL Odds, Picks, Predictions For 49ers vs. Jaguars: San Francisco Travels Well Under Kyle Shanahanby ActionNetworkNovember 20, 2021November 20, 2021In search of 49ers vs. Jaguars odds? We’ve outlined the spread and over/under in our guide to betting this NFL matchup. Leave a Reply Cancel replyYou must be logged in to post a comment.