2022 NFL Week 1 Odds Matchups Spreads Totals Bills @ Rams (TNF) Bills -1 52 Saints @ Falcons Saints -3.5 42 Browns @ Panthers Browns -4 43 49ers @ Bears 49ers -6.5
2022 NFL Week 1 Odds Matchups Spreads Totals Bills @ Rams (TNF) Bills -1 52 Saints @ Falcons Saints -3.5 42 Browns @ Panthers Browns -4 43 49ers @ Bears 49ers -6.5